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3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
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Tumor Budding: Prognostic Value in Muscle-invasive Bladder Cancer
Laura Lorenzo Soriano1, Guzmán Ordaz Jurado1, José Luis Pontones Moreno1
1Department of Urology, Hospital University La Fe, Valencia, Spain.
Urology
|April 16, 2019
Summary
Tumor budding (TB) is a significant predictor of poor prognosis in muscle-invasive bladder carcinoma (MIBC). High TB counts (>14 buds) are linked to increased cancer-specific mortality risk.
Area of Science:
- Oncology
- Pathology
- Urological Cancer Research
Background:
- Muscle-invasive bladder carcinoma (MIBC) is an aggressive malignancy.
- Accurate prognostic factors are crucial for guiding treatment decisions in MIBC.
- Tumor budding (TB), defined as small clusters of tumor cells at the invasion front, has been suggested as a potential prognostic marker.
Purpose of the Study:
- To evaluate the prognostic significance of tumor budding (TB) in muscle-invasive bladder carcinoma (MIBC).
- To determine if TB serves as an independent predictor of cancer-specific mortality in MIBC patients.
Main Methods:
- Retrospective analysis of 106 MIBC patients undergoing radical cystectomy.
- Cytokeratin AE1/AE3 immunostaining to identify and quantify TB using the "hot-spot" method.
- Multivariate analysis including clinical and molecular variables to assess independent predictors of survival.
Main Results:
- A cut-off of 14 tumor buds (TB) was identified using ROC curve analysis.
- Patients with high TB (>14 buds) had significantly shorter median survival (18.5 months) compared to low TB (≤14 buds, 69.5 months) (P=.003).
- High TB (>14 buds) was an independent predictor of mortality (OR 2.27, P=.013), with a 2% increase in mortality risk per bud.
Conclusions:
- Tumor budding (TB) is a significant independent predictor of cancer-specific mortality in muscle-invasive bladder carcinoma (MIBC).
- A threshold of 14 tumor buds effectively stratifies patients into high- and low-risk groups for mortality.
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