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11:02
Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
Published on: July 9, 2015
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Smart Mesoporous Silica Nanoparticles for Protein Delivery.
1Department of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA. HAIJUN@mailbox.sc.edu.
Nanomaterials (Basel, Switzerland)
|April 17, 2019
Summary
Mesoporous silica nanoparticles (MSN) offer versatile protein delivery due to high loading capacity and stability. This review covers protein loading factors, targeted delivery, controlled release strategies, and clinical translation challenges for MSN therapeutics.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Mesoporous silica nanoparticles (MSN) are widely studied for biomedical applications.
- Their properties include high loading capacity, surface functionalization, biocompatibility, and stability.
Purpose of the Study:
- To review factors influencing protein loading into MSN.
- To discuss strategies for targeted delivery and controlled release of proteins using MSN.
- To provide an outlook on challenges for clinical translation of protein-loaded MSN.
Main Methods:
- Literature review focusing on protein-loaded MSN.
- Analysis of factors affecting protein encapsulation efficiency.
- Examination of delivery and release mechanisms.
- Discussion of clinical translation hurdles.
Main Results:
- MSN properties significantly impact protein loading efficiency.
- Various strategies exist for targeted protein delivery and controlled release.
- Significant challenges remain for the clinical application of protein-loaded MSN.
Conclusions:
- MSN are promising carriers for protein therapeutics.
- Optimization of loading and release is crucial for efficacy.
- Overcoming clinical translation barriers is essential for therapeutic success.
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