Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A bifunctional ligand for Pd(II).

F M Chen, D E Troutner

    International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Tunnel technique combined with connective tissue graft for continuous multiple gingival recessions associated with dentin hypersensitivity: a 3-to 5-year long-term follow-up case series report].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
    Same author

    [Research progress in the relationship between periodontitis and anxiety disorders/depression disorders].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025
    Same author

    [Preliminary study on the significance of serum thyroid antibody in the selection of treatment for oral lichen planus].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025
    Same author

    [Influence of periodontal microbial homeostasis on neurodegenerative diseases and its therapeutic perspectives].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2024
    Same author

    [Preparation and biological characteristics of extracellular matrix vesicle mimetics].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2024
    Same author

    [Periodontal tissue regeneration: current therapeutic strategies and future directions in further research].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2024
    Same journal

    Photoreactive 111In-cyclodextrin inclusion complex: a new heterobifunctional reagent for antibody labeling.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    Same journal

    (S)- and (R)-[11C]nicotine and the metabolite (R/S)-[11C]cotinine. Preparation, metabolite studies and in vivo distribution in the human brain using PET.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    Same journal

    Ligands and tracers for PET studies of the 5-HT system--current status.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    Same journal

    Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    Same journal

    Attachment of 99mTc to lipid vesicles containing the lipophilic chelate dipalmitoylphosphatidylethanolamine-DTTA.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    Same journal

    A bifunctional HBED-derivative for labeling of antibodies with 67Ga, 111In and 59Fe. Comparative biodistribution with 111In-DPTA and 131I-labeled antibodies in mice bearing antibody internalizing and non-internalizing tumors.

    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology·1992
    See all related articles

    A novel bifunctional ligand creates a stable, neutral palladium (Pd(II)) complex. This inert complex can be easily conjugated to proteins, offering a new tool for antibody and biomolecule labeling.

    Area of Science:

    • Coordination Chemistry
    • Bioconjugation Chemistry

    Background:

    • Palladium complexes are widely used in catalysis and medicine.
    • Developing stable and functionalizable metal complexes is crucial for various applications.

    Purpose of the Study:

    • To synthesize and characterize a novel bifunctional ligand for palladium complexation.
    • To evaluate the stability and conjugation potential of the resulting palladium complex.

    Main Methods:

    • Synthesis of 6-(5-carboxyl pentyl)-5,7 dioxo-1,4,8, 11-tetraazaundecane ligand.
    • Complexation with Palladium(II) ions.
    • Characterization of the neutral, inert complex.
    • Assessment of stability across a wide pH range.
    • Demonstration of protein conjugation via carbodiimide coupling.

    Related Experiment Videos

    Main Results:

    • High yield formation of a neutral, inert Pd(II) complex.
    • The complex exhibits stability over a broad pH spectrum.
    • Successful conjugation to proteins was achieved using the carboxylic acid side arm.

    Conclusions:

    • The synthesized ligand effectively forms a stable and inert Pd(II) complex.
    • This complex is amenable to bioconjugation, making it suitable for labeling biomolecules like antibodies.