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eeFit: a Microsoft Excel-embedded program for interactive analysis and fitting of experimental dose-response data.

Michel Vivaudou1,2

  • 1Institut de Biologie Structurale (IBS), University of Grenoble Alpes, CEA, CNRS, IBS, 38000 Grenoble, France.

Biotechniques
|April 17, 2019
PubMed
Summary

We developed eeFit, an Excel-based software for fitting experimental dose-response data. This user-friendly tool simplifies curve fitting for various biological assays, offering accurate results comparable to commercial software.

Keywords:
Microsoft Excelcurve fittingdose–effecthill functionion channelnon-linear least-squares regressionreceptorsoftwarespreadsheet

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Area of Science:

  • Pharmacology
  • Biophysics
  • Computational Biology

Background:

  • Dose-response data analysis is crucial in pharmacology and drug discovery.
  • Existing software for curve fitting can be complex and require specialized knowledge.
  • Integration with common data analysis tools like Excel is often desired.

Purpose of the Study:

  • To introduce eeFit, a novel software program for fitting experimental dose-response data.
  • To provide a user-friendly, Excel-integrated solution for curve fitting.
  • To enable interactive graphing and fitting of various dose-effect models.

Main Methods:

  • Development of eeFit, an Excel-embedded software program.
  • Integration of non-linear least-squares fitting algorithms within Excel.
  • Implementation of standard Hill models for activation/inhibition and biphasic effects.
  • Benchmarking eeFit against commercial software (Origin) for accuracy and convergence.

Main Results:

  • eeFit seamlessly integrates with Excel, allowing data, plots, and results in one file.
  • The software requires no advanced Excel or fitting expertise.
  • eeFit accurately fits dose-response data using various models, including Hill equations.
  • Benchmarking showed eeFit provides equivalent or superior accuracy and convergence compared to Origin, with enhanced ease of use.

Conclusions:

  • eeFit offers an accessible and efficient solution for analyzing experimental dose-response data.
  • The software simplifies complex curve fitting tasks for researchers in pharmacology and related fields.
  • eeFit's integration with Excel enhances workflow efficiency and data management.