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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

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Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor

Chin-King Looi1, Felicia Fei-Lei Chung2, Chee-Onn Leong3,4

  • 1School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia.

Journal of Experimental & Clinical Cancer Research : CR
|April 17, 2019
PubMed
Abstract

Insights

Pancreatic cancer

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Pancreatic cancer has a low survival rate (<5%) and is often diagnosed late.
  • Limited effective treatments exist for advanced pancreatic cancer.
  • Pancreatic tumors are resistant to therapy and create an immunosuppressive tumor microenvironment (TME).

Purpose of the Study:

  • To review the unique properties of the pancreatic tumor microenvironment (TME).
  • To explore strategies for overcoming TME-mediated resistance to immunotherapy.
  • To discuss combination therapies for advanced pancreatic cancer.

Main Methods:

  • Summarized evidence on pancreatic cancer TME properties.
  • Reviewed strategies to overcome TME resistance.
  • Examined combination therapies targeting TME barriers.

Main Results:

  • Pancreatic TME properties contribute to immunotherapy resistance.
  • Combination therapies can enhance T cell priming and reduce immunosuppression.
  • Breaking down the desmoplastic barrier improves lymphocyte infiltration.

Conclusions:

  • Understanding pancreatic tumor immunology is crucial for improving clinical trial outcomes.
  • Targeting the pancreatic TME is key to better patient prognosis.
  • Future efforts aim to make pancreatic cancer a treatable condition.
Keywords:
ImmunotherapyPancreatic cancerTumor microenvironment

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