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Quality control limits for microdilution susceptibility tests with norfloxacin.
Journal of Clinical Microbiology
|January 1, 1987
Summary
This study establishes new quality control limits for norfloxacin microdilution susceptibility testing. These updated ranges ensure accurate antibiotic susceptibility testing (AST) for key bacterial pathogens.
Area of Science:
- Clinical Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Accurate antibiotic susceptibility testing (AST) is crucial for effective treatment of bacterial infections.
- Norfloxacin is a widely used fluoroquinolone antibiotic.
- Established quality control (QC) limits are essential for reliable AST results.
Purpose of the Study:
- To define and propose new quality control limits for microdilution susceptibility tests using norfloxacin.
- To ensure the accuracy and reproducibility of norfloxacin AST across different laboratories.
Main Methods:
- A multilaboratory study was conducted.
- Microdilution susceptibility tests were performed using standard bacterial strains.
- Proposed quality control limits were determined for specific bacterial species.
Main Results:
- Proposed QC limits for norfloxacin were established for Escherichia coli (0.03-0.125 µg/ml), Pseudomonas aeruginosa (1.0-4.0 µg/ml), Staphylococcus aureus (0.5-2.0 µg/ml), and Streptococcus faecalis (2.0-8.0 µg/ml).
- The proposed limits for Streptococcus faecalis represent a revision of previously recommended ranges.
Conclusions:
- The proposed QC limits provide a standardized framework for norfloxacin AST.
- Implementation of these limits will enhance the reliability of AST, aiding in appropriate antibiotic selection and patient management.