Related Experiment Video

Updated: Jan 26, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
06:39

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease

Published on: February 18, 2020

7.2K

High Lp(a) associated with very premature coronary heart disease

Dalia Mobarek1, Pamela A Karasik1, Meenakshi Tomer2

  • 1Department of Medicine, Section of Hematology and Medical Oncology, Veterans Affairs Medical Center, Washington, DC, USA; Department of Medicine, Section of Hematology and Medical Oncology, George Washington University, Washington, DC, USA.

Journal of Clinical Lipidology
|April 17, 2019
PubMed

Insights

High levels of lipoprotein(a) (Lp(a)) are linked to coronary heart disease (CHD). This case highlights a young woman with extremely high Lp(a) and premature CHD, suggesting Lp(a) as a key risk factor even without traditional risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Genetics and Molecular Biology

Background:

  • Elevated lipoprotein(a) [Lp(a)] is an established risk factor for coronary heart disease (CHD).
  • The specific association between high Lp(a) levels and very premature CHD (onset before age 30) remains incompletely understood.

Observation:

  • A case study involving a young woman presenting with exceptionally high Lp(a) levels.
  • The patient exhibited signs of accelerated coronary heart disease.

Findings:

  • The observed accelerated CHD in the young patient was not attributable to conventional cardiovascular risk factors.
  • This suggests a strong, independent role for very high Lp(a) in the pathogenesis of early-onset CHD.

Implications:

  • Very high Lp(a) may be a critical, under-recognized risk factor for premature coronary heart disease in younger individuals.
  • Further research into Lp(a) as a primary driver of early-onset CHD is warranted.
  • Clinical awareness and screening for elevated Lp(a) in young patients with CHD are crucial for risk stratification and management.

Keywords:
CholesterolCoronary heart diseaseLp(a)Risk factorsYoung adults

More Related Videos

Analysis of Coronary Vessels in Cleared Embryonic Hearts08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

8.6K
Author Spotlight: Innovative Technique for Coronary Angiography in Marginal Donors06:25

Author Spotlight: Innovative Technique for Coronary Angiography in Marginal Donors

Published on: July 12, 2024

841

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
958
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
409
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
238
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
480
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.0K
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
358