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Published on: August 18, 2020
Relationship between neuropsychological behavior and brain white matter in first-episode psychosis
Andreia V Faria1, Jeffrey Crawford2, Chenfei Ye3
1Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).
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