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Updated: Jan 26, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach
Malcolm E Winkler1, Donald A Morrison2
1Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA winklerm@indiana.edu.
Abstract:
DNA uptake by natural competence is a central process underlying the genetic plasticity, biology, and virulence of the human respiratory opportunistic pathogen Streptococcus pneumoniae A study reported in this issue (J. Slager, R. Aprianto, and J.-W. Veening, J. Bacteriol. 201:e00780-18, https://doi.org/10.1128/JB.00780-18) combined deep-genome annotation and high-resolution transcriptome analyses to considerably extend the previous model of temporal regulation of competence at the operon and component gene levels. That extended study also provides a playbook for updating, refining, and extending genomic data sets and making them publicly available.
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