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[Skin Changes in POEMS Syndrome].

Satoshi Kuwabara1

  • 1Department of Neurology, Graduate School of Medicine, Chiba University.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|April 17, 2019
PubMed
Summary

Skin changes are early signs of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes). Recognizing these symptoms aids in early diagnosis and treatment, significantly improving patient outcomes.

Area of Science:

  • Dermatology
  • Hematology
  • Neurology

Background:

  • POEMS syndrome presents with frequent and early skin changes like edema, hyperpigmentation, hypertrichosis, and hemangioma.
  • The exact pathogenesis of these skin symptoms is not fully understood, though vascular endothelial growth factor (VEGF) and melanin deposition are implicated.
  • Early identification of skin manifestations is crucial for timely diagnosis and intervention.

Purpose of the Study:

  • To highlight the significance of skin changes in the early diagnosis of POEMS syndrome.
  • To underscore the importance of understanding skin manifestations for clinical management.
  • To provide an overview of recent therapeutic advancements.

Main Methods:

  • Review of clinical manifestations of POEMS syndrome, focusing on dermatological findings.

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  • Discussion of proposed pathogenetic mechanisms for skin symptoms.
  • Summary of novel treatment strategies introduced since 2000.

    • Main Results:

    • Skin changes are consistent early indicators of POEMS syndrome.
    • Novel treatments available since 2000 have led to significant improvements in patient outcomes.
    • Understanding skin manifestations is key to diagnosing this complex disorder.

    Conclusions:

    • Prompt recognition of skin changes aids in the early diagnosis and management of POEMS syndrome.
    • Advances in treatment have improved the prognosis for patients with POEMS syndrome.
    • Further research into the pathogenesis of skin symptoms may lead to even better therapeutic strategies.