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Platelet Activation and Inflammation in Hypertensive Children with Non-dipper and Dipper Status

Nuran Cetin1, Asli Kavaz Tufan

  • 1Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey. nurancetin17@hotmail.com.

Iranian Journal of Kidney Diseases
|April 17, 2019
PubMed

Insights

Non-dipper hypertension in children is linked to higher mean platelet volume (MPV) and neutrophil counts. These markers, particularly MPV, may help identify children with non-dipper hypertension and associated risks.

Area of Science:

  • Pediatrics
  • Cardiology
  • Hematology

Background:

  • Non-dipper hypertension is associated with increased risk of target organ damage.
  • Inflammation and platelet activation play roles in hypertension pathogenesis.

Purpose of the Study:

  • To investigate the association between ambulatory blood pressure monitoring (ABPM) values and inflammation/platelet indices.
  • To compare these markers in children with dipper and non-dipper hypertension.

Main Methods:

  • Retrospective study of 153 patients undergoing ABPM.
  • Categorization into non-dipper hypertensive, dipper hypertensive, and normotensive groups.
  • Analysis of neutrophil count, platelet indices (MPV, PCT, PDW), NLR, and PLR.

Main Results:

  • Non-dipper and dipper hypertensive groups showed higher neutrophil counts and MPV than normotensive controls.
  • Logistic regression identified significant associations between non-dipper status and MPV/platelet count.
  • Receiver operating characteristic analysis indicated MPV (AUC 0.709) and platelet count (AUC 0.604) can predict non-dipper status.

Conclusions:

  • Elevated MPV and neutrophil count may indicate increased hypertension risk in children.
  • MPV and platelet count show potential as indicators for identifying non-dipper status in pediatric hypertension.
Abstract

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