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The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy

Muwen Yang1, Xingsong Qin1, Guangyuan Qin2

  • 1Department of Breast Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China, xyzheng@cmu.edu.cn.

Oncotargets and Therapy
|April 17, 2019
PubMed
Abstract

Insights

Interleukin-1 receptor-associated kinase 1 (IRAK1) expression decreases after neoadjuvant chemotherapy (NCT) in breast cancer. Lower IRAK1 levels correlate with better outcomes, suggesting IRAK1 as a prognostic marker for NCT efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Interleukin-1 receptor-associated kinase 1 (IRAK1) is implicated in tumor development and progression.
  • IRAK1 is a known driver of breast cancer metastasis and paclitaxel resistance.
  • The role of IRAK1 in neoadjuvant chemotherapy (NCT) for breast cancer requires further elucidation.

Purpose of the Study:

  • To investigate the association between IRAK1 expression and clinicopathological features in breast cancer patients undergoing NCT.
  • To evaluate IRAK1 as a potential prognostic biomarker for survival in breast cancer patients treated with NCT.

Main Methods:

  • Analysis of clinical and mRNA microarray data from 1,085 breast cancer patients in The Cancer Genome Atlas.
  • Immunohistochemistry to assess IRAK1 protein expression.
  • Bioinformatic analysis using Human Protein Atlas, String database, cBioPortal, and GEO datasets.

Main Results:

  • IRAK1 expression was significantly downregulated post-NCT.
  • Decreased IRAK1 levels after NCT correlated with reduced tumor size.
  • Higher IRAK1 expression, both pre- and post-NCT, was associated with shorter survival periods.

Conclusions:

  • IRAK1 expression patterns in breast cancer patients treated with NCT were clarified.
  • IRAK1 may serve as a valuable prognostic indicator for breast cancer patients.
  • IRAK1 could potentially be used to evaluate the efficacy of NCT in breast cancer.
Keywords:
IRAK1bioinformaticsbreast cancerneoadjuvant chemotherapysurvival

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