Related Experiment Video
Updated: Jan 26, 2026
06:22
Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats
Published on: April 14, 2023
1.7K
Management of recurrent Ewing sarcoma: challenges and approaches
David Van Mater1, Lars Wagner1
1Department of Pediatrics, Division of Hematology/Oncology, Duke University, Durham, NC, USA, lars.wagner@duke.edu.
Oncotargets and Therapy
|April 17, 2019
Summary
Relapsed Ewing sarcoma lacks a standard treatment, posing challenges for long-term survival. Clinical trials are crucial for patients with recurrent Ewing sarcoma due to limited knowledge and low cure rates.
Area of Science:
- Pediatric Oncology
- Medical Oncology
- Sarcoma Research
Background:
- Relapse is a significant clinical challenge in Ewing sarcoma despite advances in initial treatment.
- Current management strategies for recurrent Ewing sarcoma lack standardization and comparative data.
- Identifying prognostic factors is essential for guiding therapy and patient counseling.
Purpose of the Study:
- To review current knowledge and address common questions regarding the management of relapsed Ewing sarcoma.
- To provide an update on emerging therapeutic strategies for recurrent Ewing sarcoma.
- To emphasize the importance of clinical trial enrollment for patients with relapsed disease.
Main Methods:
- Literature review of existing studies on Ewing sarcoma relapse.
- Analysis of prognostic factors influencing outcomes in recurrent disease.
- Discussion of various chemotherapy regimens and local control measures.
Main Results:
- Several prognostic factors identified but no single approach is standard for recurrent Ewing sarcoma.
- Various chemotherapy regimens show response rates, but comparative efficacy is unproven.
- Optimal duration of salvage therapy and role of local control remain undetermined.
Conclusions:
- Enrollment in clinical trials is strongly recommended for patients with relapsed Ewing sarcoma.
- Further research is needed to establish standard-of-care and improve outcomes.
- Addressing knowledge gaps is critical for improving the management of this rare cancer.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
6.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.3K
01:20Frustration and Conflict: Approach-Approach, Approach-Avoidance
505
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
505
01:26Tonsillitis II: Management
417
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
417
01:29Impression Management Techniques I: Managing Appearances
207
Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
207
01:19Management of Insomnia
580
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
580
01:19Managing Impressions
169
Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
169