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Updated: Jan 26, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
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Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

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Association between polymorphisms in MRE11 and HIV-1 susceptibility and AIDS progression in a northern Chinese MSM

Chang Liu1, Yuandong Qiao1, Lidan Xu1

  • 1Laboratory of Medical Genetics, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, China.

The Journal of Antimicrobial Chemotherapy
|April 17, 2019
PubMed
Abstract

Insights

The MRE11 gene plays a role in DNA damage repair and HIV-1 infection. A specific single nucleotide polymorphism (SNP), rs10831234, in the MRE11 gene is associated with increased susceptibility to HIV-1 infection in men who have sex with men.

Area of Science:

  • Genetics
  • Immunology
  • Virology

Background:

  • DNA damage repair (DDR) genes are implicated in HIV-1 infection.
  • The MRE11 gene, crucial for homologous recombination and DNA repair, affects HIV-1 replication.
  • The role of MRE11 single nucleotide polymorphisms (SNPs) in HIV-1 infection and AIDS progression is not well understood.

Purpose of the Study:

  • To investigate the association between MRE11 gene SNPs and HIV-1 infection susceptibility.
  • To explore the potential impact of these SNPs on AIDS progression.

Main Methods:

  • Genotyping of five MRE11 SNPs (rs2155209, rs10831234, rs13447720, rs601341, rs11020803) in 434 HIV-1 infected MSM and 431 healthy controls.
  • Validation of significant findings in an independent cohort of 409 HIV-1 infected MSM and 403 healthy controls.
  • Haplotype association analyses were performed.

Main Results:

  • The MRE11 rs10831234 SNP showed significant allele frequency differences between HIV-1 infected cases and controls (P=0.005).
  • Association between rs10831234 and HIV-1 infection susceptibility was confirmed in dominant and additive models (P=0.005, P=0.006).
  • Significant associations were replicated in the validation set and remained significant after Bonferroni correction. Haplotypes Crs11020803Crs10831234 and Trs11020803Trs10831234 showed significant differences.

Conclusions:

  • The MRE11 rs10831234-T allele is associated with an increased risk of HIV-1 infection.
  • This finding highlights the potential role of MRE11 genetic variations in HIV-1 susceptibility.

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