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Mortality in patients with systemic lupus erythematosus in Colombia: a case series

David Aguirre-Valencia1,2, Ana Suárez-Avellaneda2, Vanessa Ocampo-Piraquive2

  • 1GIRAT: Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Fundación Valle del Lili and Universidad Icesi, Cali, Colombia.

Clinical Rheumatology
|April 17, 2019
PubMed

Insights

Systemic lupus erythematosus (SLE) deaths were mainly due to active disease and lupus nephritis. Patients often had severe complications like antiphospholipid syndrome, requiring intensive treatment and hospitalization.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with significant mortality.
  • Understanding mortality patterns is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify and describe the primary causes of death in SLE patients.
  • To analyze factors associated with mortality in a Colombian SLE cohort.

Main Methods:

  • Retrospective review of SLE patient records from January 2011 to June 2017.
  • Extraction and analysis of causes of death and associated clinical variables.

Main Results:

  • 49 deaths in 1776 SLE patients; predominantly women (89.8%).
  • Leading causes of death: SLE activity (44.9%), lupus nephritis (LN) types IV and VI (77.6%), and antiphospholipid syndrome (16.3%).
  • Patients exhibited high SLE disease activity index (SLEDAI-2K) scores and persistent hypocomplementemia.

Conclusions:

  • Refractory SLE activity and nosocomial infections were key mortality drivers.
  • High SLEDAI, severe LN, antiphospholipid syndrome, and hypocomplementemia predicted mortality.
  • These factors necessitated aggressive immunosuppression and prolonged hospital stays.
Abstract

Keywords:
ImmunosuppressionMortalityOutcomesSLEDAISystemic lupus erythematosus

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