Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is a Sensory System?01:31

What is a Sensory System?

101.0K
Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
101.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Neurons: The Axon01:21

Neurons: The Axon

7.0K
Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
7.0K
Sensory Modalities01:15

Sensory Modalities

3.8K
Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...
3.8K
What is Natural Selection?01:32

What is Natural Selection?

126.6K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.6K
Sensory Memory01:14

Sensory Memory

655
Sensory memory captures information from the environment in its original form for a very brief duration, just long enough to be exposed to visual, auditory, and other senses. This type of memory is detailed and rich but quickly lost unless certain strategies are employed to transfer it into short-term or long-term memory. Sensory information is continuously bombarding the human brain, yet only a small fraction is absorbed, as most of it does not significantly impact daily life. For instance,...
655

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial.

Annals of neurology·2026
Same author

Occam's Razor Revisited: Myasthenia Gravis and Thyroid Ophthalmopathy.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

Manipulation of the Myc Interactome to Enhance Nerve Regeneration in a Murine Model.

Annals of neurology·2024
Same author

Combined PTEN Knockdown and Local Insulin in Chronic Experimental Diabetic Neuropathy.

Diabetes·2023
Same author

Survival of compromised adult sensory neurons involves macrovesicular formation.

Cell death discovery·2022
Same author

Repurposed major urinary protein pheromones and adult sensory neurons: roles in neuron plasticity and experimental diabetes.

American journal of physiology. Endocrinology and metabolism·2022

Related Experiment Video

Updated: Jan 26, 2026

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
08:37

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections

Published on: December 9, 2014

10.5K

Selective Sensory Axon Reinnervation and TRPV1 Activation.

T Poitras1, A Chandrasekhar1, L McCoy1

  • 1Division of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, 132A-Clinical Sciences Building, 11350 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Molecular Neurobiology
|April 17, 2019
PubMed
Summary

Low doses of capsaicin activate TRPV1 channels, promoting sensory neuron regeneration and skin reinnervation. High doses cause neurodegeneration, highlighting a dose-dependent effect on nerve repair.

Keywords:
CapsaicinPeripheral nerveRegenerationSensory neuronsTRPV1

More Related Videos

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.4K
Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria
06:55

Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria

Published on: August 4, 2022

2.2K

Related Experiment Videos

Last Updated: Jan 26, 2026

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
08:37

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections

Published on: December 9, 2014

10.5K
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.4K
Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria
06:55

Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria

Published on: August 4, 2022

2.2K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Peripheral nerve regeneration is crucial but often limited following injury or disease.
  • Current strategies for enhancing nerve regeneration lack specificity.
  • TRPV1 channels are implicated in sensory neuron function and response to stimuli.

Purpose of the Study:

  • To investigate the role of TRPV1 channel activation in peripheral neuron regeneration.
  • To determine the dose-dependent effects of capsaicin, a TRPV1 agonist, on sensory neuron outgrowth and reinnervation.
  • To assess the therapeutic potential of TRPV1 modulation for improving nerve repair.

Main Methods:

  • In vitro studies using sensory neurons to assess axon outgrowth and calcium signaling in response to capsaicin.
  • In vivo studies in mice with sciatic nerve crush injury, applying capsaicin locally.
  • Assessment of motor, myelinated, and epidermal axon recovery, as well as thermal sensation.
  • Utilized TRPV1 knockout mice to confirm the specificity of capsaicin's effects.

Main Results:

  • Low-dose capsaicin significantly enhanced sensory neuron outgrowth and skin reinnervation in vivo, approaching contralateral levels.
  • High-dose capsaicin induced neurodegeneration, demonstrating a bidirectional, dose-dependent effect.
  • TRPV1 activation increased neuronal calcium and TRPV1 mRNA levels.
  • TRPV1 null mice showed impaired thermal sensation recovery and lacked capsaicin-induced hyperinnervation.
  • No significant impact on motor or myelinated axon recovery was observed.

Conclusions:

  • TRPV1 channel activation, specifically at low doses, can selectively augment cutaneous innervation by thermosensitive sensory axons.
  • Modulating TRPV1 channels offers a potential strategy to enhance specific aspects of peripheral nerve regeneration.
  • The findings highlight a novel approach to nerve repair by targeting specific neuronal populations.