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Updated: Jan 26, 2026

Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
Published on: March 9, 2018
Electric modeling and characterization of pulsed high-voltage nanoelectrospray ionization sources by a miniature ion
Zuqiang Xu1, Hanyan Wu2, Yang Tang1
1School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Abstract:
A better understanding of nanoelectrospray ionization (nano-ESI) would be beneficial in further improving the performances of nano-ESI. In this work, the pulsed high-voltage (HV) nano-ESI has been electrically modeled and then systematically characterized by both voltage-current and mass spectrometry measurements. First, the equivalent resistance of a nano-ESI source changes with respect to both emitter tip diameter and the HV applied. Increased voltage could improve both spray current and ionization efficiency of the pulsed HV nano-ESI. Compared with conventional DC HV method, a pulsed HV has less heating effect on the capillary tip and thus allowing the application of a much higher voltage onto a nano-ESI source. As a result, a pulsed HV nano-ESI could further boost the ionization efficiency of nano-ESI by employing even higher voltages than conventional DC nano-ESI sources.
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