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Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence.

R T Kirkland, B S Keenan, J L Probstfield

    JAMA
    |January 23, 1987
    PubMed
    Summary
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    Testosterone increases during puberty, leading to a significant decrease in high-density lipoprotein cholesterol (HDL-C) levels in boys. This study confirms testosterone

    Area of Science:

    • Endocrinology
    • Lipid Metabolism
    • Adolescent Health

    Background:

    • Pubertal development in boys is associated with changes in lipid profiles.
    • A decrease in high-density lipoprotein cholesterol (HDL-C) is often observed during male puberty.
    • The role of testosterone in this HDL-C reduction requires further elucidation.

    Purpose of the Study:

    • To investigate the relationship between increasing plasma testosterone concentrations and decreasing HDL-C levels in adolescent boys.
    • To determine if testosterone is a significant factor influencing HDL-C during pubertal development.

    Main Methods:

    • Phase I: Cross-sectional analysis of 57 boys (10-17 years) across four pubertal stages, correlating testosterone and HDL-C.
    • Phase II: Intervention study with 14 boys with delayed adolescence treated with testosterone enanthate, monitoring HDL-C.

    Related Experiment Videos

  • Phase III: Longitudinal observation of 13 boys with delayed adolescence undergoing spontaneous puberty, tracking testosterone and HDL-C.

    • Main Results:

    • Increasing testosterone levels correlated with decreasing HDL-C levels across pubertal stages (Phase I).
    • Testosterone administration in hypogonadal boys led to significant HDL-C reduction (Phase II).
    • Spontaneous pubertal development showed a similar inverse relationship between testosterone and HDL-C (Phase III).

    Conclusions:

    • Plasma testosterone concentration is a significant determinant of HDL-C levels in adolescent males.
    • The findings suggest testosterone plays a key role in the pubertal decline of HDL-C.
    • Further research may explore the direct mechanisms linking testosterone to HDL-C changes.