[Central Aortic Pressure: Reference and Diagnostic Values]

Area of Science:

• Cardiovascular physiology
• Diagnostic indices development
• Public health research

Background:

• Central aortic pressure (CAP) parameters lack standardized reference and diagnostic indices, limiting clinical application.
• Accurate CAP assessment is vital for understanding cardiovascular health and managing hypertension.
• Previous research has not established population-specific CAP values for Novosibirsk.

Purpose of the Study:

• To determine reference values and diagnostic thresholds for central aortic pressure (CAP) parameters in the general population of Novosibirsk.
• To establish diagnostic categories for CAP based on established brachial arterial pressure (BP) levels.
• To provide a foundation for improved cardiovascular risk assessment using CAP.

Main Methods:

• Applanation tonometry using the SphygmoCor system on 327 individuals (155 men, 172 women) aged 25-44.
• Nonparametric methods (CLSI guidelines) to derive 95% percentile intervals for CAP parameters.
• Determination of diagnostic thresholds and categories based on brachial BP levels and risk estimates.

Main Results:

• Reference values for CAP parameters: pulse pressure (18-43 mm Hg), amplification of pulse pressure (5-24 mm Hg), and augmentation index (-8.8-40%).
• Defined CAP diagnostic categories: optimal (<110/80), normal (110/80-114/84), high normal (115/85-124/89), and hypertension (>125/90 mm Hg).
• Established sensitivity and specificity for left ventricular hypertrophy related to CAP thresholds.

Conclusions:

• Reference values, diagnostic thresholds, and categories for CAP parameters have been successfully determined for the 25-44 age group in Novosibirsk.
• The established CAP indices are essential for clinical practice and future cardiovascular research.
• Further investigation into these CAP parameters is warranted to fully understand their clinical utility.