[Possibilities of estimation of breast cancer targeted therapy cardiotoxicity in routine clinical practice]
S I Korneeva1, S V Povetkin1, O I Kiseleva1
1Kursk State Medical University (KSMU), K. Marx st., 3, Kursk 305041, Russia.
Aims:
To estimate cardiotoxicity of targeted therapy of breast cancer by the results of methods of investigation, which are used in routine clinical practice.
Methods And Results:
We have made a retrospective analysis of medical documentation of patients with breast cancer, which are given trastuzumab in mono regimen and as a part of antitumor chemotherapy. An average number of chemotherapy's courses is 10,3±1,9. Such methods as echocardiography and electrocardiography, physical examination are ordinary used to estimate the cardiotoxicity in routine clinical practice. Revealed dynamic of indices shows that pathological changes of cardiovascular system developed during using trastuzumab do not reach the level of generally accepted sings of cardiotoxicity.
Conclusion:
Methods of diagnostics, which are used in routine clinical practice nowadays do not allow to reveal the early sings of myocardial damage. The question about commissioning of modern technologies in aim of early examination of myocardial dysfunction is still relevant.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
What are Estimates?
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
Estimation of k and VD of Aminoglycosides
Gene Therapy
Characteristics of Practical Op Amps
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...


