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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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Target Controllability of Two-Layer Multiplex Networks Based on Network Flow Theory.

Kun Song, Guoqi Li, Xumin Chen

    IEEE Transactions on Cybernetics
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    Controlling two-layer multiplex networks requires minimum control sources. This study introduces a maximum flow-based algorithm (MFTP) to efficiently identify the minimum sources needed for target controllability in complex networks.

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    Area of Science:

    • Network Science
    • Control Theory
    • Complex Systems

    Background:

    • Multiplex networks are prevalent in real-world systems.
    • Controlling these networks, especially layer-specific control, presents significant challenges.
    • Existing methods struggle with optimizing control source allocation in multi-layer networks.

    Purpose of the Study:

    • To determine the minimum number of control sources for target controllability in two-layer multiplex networks.
    • To address the constraint that control sources interact with only one layer.
    • To develop an efficient algorithm for this optimization problem.

    Main Methods:

    • Formulating the problem as a path cover problem.
    • Converting the path cover problem into a maximum network flow problem.
    • Developing and applying the maximum flow-based target path-cover (MFTP) algorithm.

    Main Results:

    • The study proves that the target controllability issue is equivalent to a specific path cover problem.
    • The MFTP algorithm is rigorously shown to find the minimum number of control sources.
    • The MFTP algorithm efficiently solves the maximum network flow problem for this application.

    Conclusions:

    • The MFTP algorithm provides an optimal solution for minimum control source allocation in two-layer multiplex networks.
    • This research offers a computationally efficient method for enhancing network controllability.
    • The findings have broad implications for the target control of various real-world network systems.