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Related Experiment Videos

[A clinical bacteriological efficacy study on a fosfomycin otic solution].

K Deguchi, N Yokota, S Tanaka

    The Japanese Journal of Antibiotics
    |September 1, 1986
    PubMed
    Summary

    Fosfomycin (FOM) otic solution effectively treats suppurative otitis media, showing excellent activity against resistant bacteria like Staphylococcus aureus and Pseudomonas aeruginosa. Its low ototoxicity makes it a useful topical treatment.

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    Pharmaceutical research·2013

    Area of Science:

    • Otolaryngology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Suppurative otitis media is a common infection requiring effective topical treatments.
    • Antibiotic resistance is a growing concern in managing bacterial ear infections.

    Purpose of the Study:

    • To evaluate the efficacy and antibacterial activity of Fosfomycin (FOM) otic solution in treating suppurative otitis media.
    • To assess FOM's activity against common bacterial pathogens, including multi-drug resistant strains.

    Main Methods:

    • A clinical trial involving 587 patients with suppurative otitis media.
    • Bacteriological investigation and Minimum Inhibitory Concentration (MIC) determination for FOM and other antibiotics.
    • Assessment of FOM concentration in the tympanic cavity and its ototoxicity.

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    Main Results:

    • FOM demonstrated excellent activity against Staphylococcus aureus (including methicillin-resistant strains) and Pseudomonas aeruginosa.
    • MIC values indicated that FOM concentrations in the tympanic cavity are likely sufficient for bacterial eradication.
    • Low ototoxicity was observed, attributed to FOM's mechanism of inhibiting bacterial cell wall synthesis.

    Conclusions:

    • 3% Fosfomycin (FOM) otic solution is a remarkably useful topical preparation for suppurative otitis media.
    • FOM shows significant potential as a treatment option, particularly against resistant bacterial strains.