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Updated: Jan 26, 2026
04:39
A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter
Published on: June 13, 2025
673
One-Pot, Three-Component Approach to Diarylmethylphosphonates: A Direct Entry to Polycyclic Aromatic Systems
Sure Siva Prasad1, Dileep Kumar Singh1, Ikyon Kim1
1College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences , Yonsei University , 85 Songdogwahak-ro , Yeonsu-gu, Incheon 21983 , Republic of Korea.
The Journal of Organic Chemistry
|April 17, 2019
Summary
A novel three-component reaction efficiently synthesizes diarylmethylphosphonates from aldehydes, electron-rich arenes, and phosphites. Subsequent modifications allow for the rapid construction of complex polycyclic aromatic systems.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Developing efficient synthetic methodologies is crucial for accessing novel chemical structures.
- Three-component reactions offer atom economy and step efficiency in organic synthesis.
Purpose of the Study:
- To develop a new three-component reaction for synthesizing diarylmethylphosphonates.
- To explore the utility of the synthesized phosphonates for constructing polycyclic aromatic systems.
Main Methods:
- A three-component reaction involving aldehydes, electron-rich (hetero)arenes, and trialkyl phosphite.
- Mild reaction conditions were employed.
- One- or two-step synthetic manipulations of the products.
Main Results:
- Facile access to a wide range of diarylmethylphosphonates was achieved.
- The synthesized compounds served as versatile intermediates.
- Several polycyclic (hetero)aromatic systems were efficiently synthesized.
Conclusions:
- A novel and efficient three-component reaction for diarylmethylphosphonate synthesis has been established.
- This methodology provides a facile route to complex polycyclic aromatic compounds.
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