Related Experiment Video
Updated: Jan 26, 2026
08:12
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
6.0K
Circulating microRNAs in human obesity: a systematic review
Alejandra Ortiz-Dosal1, Patricia Rodil-García1, Luis A Salazar-Olivo1
1a Division of Molecular Biology, Institute Potosino of Scientific and Technological Research , San Luis Potosí , México.
Summary
This study reviewed circulating microRNAs (c-miRNAs) in human obesity, identifying 33 dysregulated c-miRNAs. These molecules may influence fatty acid metabolism and the PI3K/Akt pathway, contributing to obesity development.
Area of Science:
- Biochemistry
- Genetics
- Metabolic Research
Background:
- MicroRNAs (miRNAs) show differential expression in human obesity.
- This suggests a role for miRNAs in obesity development and associated disorders.
Purpose of the Study:
- To systematically review circulating microRNAs (c-miRNAs) dysregulated in human obesity.
- To predict potential target genes of these dysregulated c-miRNAs.
Main Methods:
- Systematic review of PubMed database for studies on c-miRNAs and human obesity.
- Bioinformatic analysis to identify target genes and pathways for c-miRNAs with multiple independent reports.
Main Results:
- 33 c-miRNAs were found to be dysregulated in individuals with obesity compared to lean controls.
- Bioinformatic analysis indicated that these c-miRNAs target genes involved in fatty acid metabolism and the PI3K/Akt pathway.
Conclusions:
- The identified dysregulated c-miRNAs and their predicted targets offer insights into obesity pathogenesis.
- Further research is warranted to explore the role of these c-miRNAs in metabolic diseases and their clinical utility for obesity management.
Related Concept Videos
01:22MicroRNAs
24.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.1K
01:22MicroRNAs
3.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.9K
01:10Review and Preview
8.3K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.3K
01:13Review and Preview
10.9K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
01:24Obesity
1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
01:20Random and Systematic Errors
14.7K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.7K