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IL 6 but not TNF is linked to coronary artery calcification in patients with chronic kidney disease

Joanna Kamińska1, Marek Stopiński1, Krzysztof Mucha2

  • 1Department of Internal Diseases and Dialysis Unit, West Hospital of Saint John Paul II, Daleka 11, 05-825 Grodzisk Mazowiecki, Poland.

Cytokine
|April 17, 2019
PubMed

Insights

Interleukin-6 (IL-6) and coronary artery calcium score (CS) predict 5-year mortality in chronic kidney disease (CKD) patients. This highlights the link between inflammation, calcification, and cardiovascular risk in CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Research

Background:

  • Patients with chronic kidney disease (CKD) face elevated risks of cardiovascular disease (CVD) and mortality.
  • Early identification of mortality risk factors in CKD is crucial for timely interventions.

Purpose of the Study:

  • To evaluate specific cardiovascular biomarkers and coronary artery calcium score (CS) as predictors of 5-year all-cause mortality in CKD patients.
  • To assess the association between biomarkers, CS, and mortality across different stages of CKD.

Main Methods:

  • A cohort of 57 CKD patients (stages 3-5/ESRD) and 19 healthy controls were included.
  • Serum levels of inflammatory markers (e.g., IL-6, TNF) and adhesion molecules (e.g., VCAM1) were measured.
  • Coronary artery calcium score (CS) was assessed using computed tomography; patients were followed for 5-year mortality.

Main Results:

  • Serum levels of VCAM1, TNF, and IL-6 were higher in advanced CKD stages.
  • Elevated CS and IL-6 levels significantly increased the 5-year all-cause and cardiovascular mortality risk (over 3-fold).
  • IL-6 showed significant correlations with CS, age, renal function, and CRP.

Conclusions:

  • Interleukin-6 (IL-6) and coronary artery calcium score (CS) are significant predictors of 5-year mortality in CKD patients.
  • Chronic inflammation associated with coronary artery calcification likely contributes to cardiovascular mortality in impaired renal function.
Abstract

Keywords:
Adhesion moleculesCalcium scoreChronic kidney diseaseInterleukin 6Tumor necrosis factor

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