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Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Neurodevelopmental outcomes of extremely preterm infants in southern China: A multicenter study

, Yan Li1, Dan-Hua Meng1

  • 1Department of Neonatology, Guangxi Maternal and Child Health Hospital, Nanning, 530003, Guangxi, China.

Early Human Development
|April 17, 2019
PubMed

Insights

Extremely preterm infants (EPIs) with chorioamnionitis, moderate-to-severe bronchopulmonary dysplasia (BPD), and longer mechanical ventilation duration face higher risks of neurodevelopmental disability. Lower gestational age (GA) also increases this risk.

Area of Science:

  • Neonatal Medicine
  • Developmental Pediatrics
  • Perinatal Epidemiology

Background:

  • Extremely preterm infants (EPIs) face significant risks for adverse neurodevelopmental outcomes.
  • Understanding factors associated with these outcomes is crucial for improving care and long-term prognosis.

Purpose of the Study:

  • To assess treatment outcomes and identify associated factors for neurodevelopmental disability in EPIs in Guangxi, China.
  • To analyze the relationship between gestational age, perinatal conditions, and neurodevelopmental outcomes in EPIs.

Main Methods:

  • A retrospective study of 131 EPIs (22-28 weeks gestational age) followed up to 18-24 months.
  • Data collected included clinical characteristics, perinatal factors, and after-birth conditions from 10 hospitals in Guangxi.
  • Neurodevelopmental disability (ND) was assessed at follow-up, with comparisons made between infants with and without ND.

Main Results:

  • Of 131 infants evaluated, 35.9% were diagnosed with neurodevelopmental disability (ND).
  • Chorioamnionitis, early onset sepsis (EOS), bronchopulmonary dysplasia (BPD), and longer mechanical ventilation (MV) duration were higher in the ND group.
  • Smaller gestational age (GA) was associated with a higher incidence of ND. Chorioamnionitis and moderate-to-severe BPD were significant risk factors for ND.

Conclusions:

  • Chorioamnionitis, moderate-to-severe BPD, and duration of MV are associated with ND in EPIs.
  • Lower gestational age is a significant risk factor for neurodevelopmental disability in extremely preterm infants.
Abstract

Keywords:
Extremely preterm infantGuangxi regionNeurodevelopmental outcomePredictive factor

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