Related Experiment Video
Updated: Jan 26, 2026
07:25
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
3.8K
Amputation Risk Factors in Severely Frostbitten Patients.
Anna Carceller1,2, Casimiro Javierre3, Martín Ríos4
1Secció de Fisiologia, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain. anna.carceller@gmail.com.
Summary
Frostbite is increasingly affecting young adults in winter sports. High altitude, delayed rewarming, and less experience are key risk factors for amputation after severe frostbite injuries.
Area of Science:
- Orthopedics
- Sports Medicine
- Emergency Medicine
Background:
- Frostbite incidence is rising in healthy young adults participating in winter sports.
- Frostbite causes significant activity interruption and long-term sequelae, especially for those in cold-exposed professions.
- Limited tissue regeneration potential necessitates optimal medical management for frostbite injuries.
Purpose of the Study:
- To identify risk factors for amputation following severe frostbite.
- To evaluate the impact of various factors on frostbite prognosis in patients.
Main Methods:
- Retrospective data collection from 92 frostbitten patients.
- Analysis of factors including mountain range, mountaineering experience, rewarming time, and altitude.
Main Results:
- Several factors were identified as significant predictors of poor prognosis.
- Altitude, time elapsed before rewarming, and years of winter mountaineering expertise were crucial.
- Mountain range also played a role in the risk of amputation.
Conclusions:
- Specific environmental and patient-related factors significantly influence frostbite outcomes.
- Early rewarming and considering altitude are critical in managing severe frostbite to prevent amputation.
- Understanding these risk factors can improve medical management and patient counseling for winter sports enthusiasts and professionals.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
313
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
313
01:12Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
02:16Transcription Factors
82.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.4K
04:01Factors Affecting Solubility
36.7K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
36.7K
02:35Transcription Elongation Factors
13.6K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.6K