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Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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Identification of KIF11 As a Novel Target in Meningioma

Gerhard Jungwirth1, Tao Yu2, Mahmoud Moustafa3,4

  • 1Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, INF 400, D-69120 Heidelberg, Germany. gerhard.jungwirth@med.uni-heidelberg.de.

Cancers
|April 18, 2019
PubMed

Insights

This study identifies kinesins as key players in meningioma progression. KIF11, in particular, shows promise as a prognostic marker and therapeutic target for aggressive meningiomas.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Kinesins are crucial for intracellular transport and mitosis.
  • Their role in cancer suggests potential involvement in meningioma pathogenesis.

Purpose of the Study:

  • Investigate kinesin expression and function in meningioma.
  • Identify prognostic markers and therapeutic targets for meningioma.

Main Methods:

  • Re-analysis of microarray data (n=62) and validation in a larger cohort (n=208).
  • Immunohistochemical staining for protein expression.
  • siRNA-mediated knockdown in meningioma cell lines (Ben-Men-1, NCH93).

Main Results:

  • Five kinesins (KIFC1, KIF4A, KIF11, KIF14, KIF20A) showed differential expression in meningiomas.
  • Upregulation of these genes correlated with higher WHO grades and aggressive tumors.
  • High KIFC1, KIF11, KIF14, KIF20A mRNA levels predicted shorter progression-free survival.
  • KIF11 knockdown significantly inhibited proliferation in both cell lines.

Conclusions:

  • Kinesins play a significant role in meningioma development and progression.
  • KIF11 is a promising prognostic marker and potential therapeutic target for aggressive meningiomas.
Keywords:
KIFKIF11NCH93kinesinmeningioma

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