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Updated: Jan 26, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
Published on: February 9, 2018
Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors
Weifeng Lin1, Nir Kampf1, Ronit Goldberg1
1Department of Materials and Interfaces , Weizmann Institute of Science , Rehovot 76100 , Israel.
Abstract:
We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined as coefficient of friction μ < 10-2) via hydration lubrication at physiological salt concentrations and pressures. In contrast, vesicles sterically protected by poly(ethylene glycol) chains (PEGylation), which is the general method of choice, while being equally stable to aggregation are much poorer lubricants under these conditions, which is attributed to the relatively poor hydration of the PEG. Our approach enables the use of PC liposomes as stable superlubrication vectors in potential biomedical applications.
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