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NUT midline carcinoma in the right orbit: a case report
Tingting Ding1, Yajin Wang1, Tai Zhao1
1a Department of Oncology , Shanghai Yangpu District Shidong Hospital , Shanghai , P.R.China.
Cancer Biology & Therapy
|April 18, 2019
Summary
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare cancer. This report details the first known case of NMC originating in the eye, treated with surgery, chemotherapy, and radiation.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare malignancy characterized by a specific chromosomal translocation involving the NUT gene.
- NMC typically affects midline structures, commonly in the head and neck region.
Observation:
- This study presents the first documented case of NMC originating in the right orbit of a 60-year-old female patient.
- The tumor's location in the eye represents a novel presentation for this rare cancer.
Findings:
- The case involved a 60-year-old woman with NMC in the right orbit.
- Diagnostic and staging workup confirmed the ocular origin of the tumor.
Implications:
- This case expands the known anatomical sites for NMC, highlighting the need for awareness among ophthalmologists and oncologists.
- The successful application of a multimodality treatment approach (surgery, chemotherapy, radiotherapy, target therapy) provides a potential management strategy for this rare ocular malignancy.
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