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Updated: Jan 26, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Current strategies for therapeutic drug delivery after traumatic CNS injury
Hyun Joon Lee1,2, Jung Su Ryu3, Parminder Js Vig1,3
1Department of Neurology, University of Mississippi Medical Center, 2500 North, State Street, Jackson, MS 39216, USA.
Abstract:
Therapeutic strategies for traumatic injuries in the central nervous system (CNS) are largely limited to the efficiency of drug delivery. Despite the disrupted blood-CNS barrier during the early phase after injury, the drug administration faces a variety of obstacles derived from homeostatic imbalance at the injury site. In the late phase after CNS injury, the restoration of the blood-CNS barrier integrity varies depending on the injury severity resulting in inconsistent delivery of therapeutics. This review intends to characterize those different challenges of the therapeutic delivery in acute and chronic phases after injury and discuss recent advances in various approaches to explore novel strategies for the treatment of traumatic CNS injury.
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