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ADP-ribosylation signalling and human disease
Luca Palazzo1, Petra Mikolčević2, Andreja Mikoč2
11 Institute of Protein Biochemistry, National Research Council , Via Pietro Castellino 111, 80131 Naples , Italy.
Open Biology
|April 18, 2019
Summary
ADP-ribosylation (ADPr) is a crucial protein modification regulating cellular functions. Targeting ADPr pathways offers therapeutic potential for various human diseases, including cancer and neurological disorders.
Area of Science:
- Biochemistry and Molecular Biology
- Cellular Biology
- Genetics
Background:
- ADP-ribosylation (ADPr) is a reversible post-translational protein modification.
- It plays a critical role in regulating essential cellular processes like DNA repair, proliferation, metabolism, and immune responses.
- The balance of ADPr is maintained by ADP-ribosyl transferases and hydrolases, crucial for cellular homeostasis.
Purpose of the Study:
- To summarize recent findings on ADP-ribosylation.
- To highlight its impact on human pathophysiology.
- To underscore the therapeutic potential of targeting ADPr for molecular medicine.
Main Methods:
- Literature review of recent studies on ADP-ribosylation.
- Analysis of the role of ADPr in cellular processes and disease.
- Evaluation of therapeutic strategies targeting ADPr.
Main Results:
- Dysregulation of ADPr signaling enzymes is linked to human diseases, including neurological disorders and cancer.
- Therapeutic manipulation of ADPr has shown promise in ameliorating cardiovascular, inflammatory, autoimmune, and neurological conditions.
- Recent research supports the significant role of ADPr in human pathophysiology.
Conclusions:
- ADP-ribosylation is a vital cellular regulatory mechanism.
- Targeting ADPr presents a promising avenue for treating a range of human diseases.
- Further research into ADPr holds potential for translational and molecular medicine.
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