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Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population

Ning Gao1, Tie Guo2, Han Luo1

  • 1Department of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College in Central South University, Haikou, Hainan, 570208, China.

BMC Neurology
|April 18, 2019
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in the MMP-9 gene were investigated for their association with ischemic stroke (IS) risk. The rs3787268 polymorphism was found to increase IS risk in a southern Chinese Han population.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Background:

  • Stroke is a leading cause of disability globally.
  • Matrix metalloproteinase-9 (MMP-9) is implicated in cardiovascular disease risk.
  • Understanding genetic predispositions to ischemic stroke (IS) is crucial.

Purpose of the Study:

  • To investigate the association between MMP-9 gene single nucleotide polymorphisms (SNPs) and IS risk.
  • To analyze the rs3787268 polymorphism in a southern Chinese Han population.
  • To explore the role of MMP-9 in IS pathogenesis.

Main Methods:

  • Case-control study with 250 IS patients and 250 healthy controls.
  • Genotyping performed using the Agena MassARRAY system.
  • Statistical analysis included chi-squared tests, genetic models, and logistic regression.

Main Results:

  • The rs3787268 polymorphism showed a significant association with increased IS risk.
  • Specific genotypes (G/A, A/A) and haplotypes (C/G) demonstrated correlations with IS risk.
  • Odds ratios and confidence intervals indicated a heightened risk associated with certain MMP-9 SNP variations.

Conclusions:

  • The rs3787268 locus in the MMP-9 gene is a potential risk factor for IS in the studied population.
  • These findings contribute to understanding the genetic underpinnings of IS.
  • Further research into MMP-9's role in IS pathogenesis is warranted.
Abstract

Keywords:
Case-control studyIschemic strokeMMP-9Single nucleotide polymorphism

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