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An innate interaction between IL-18 and the propeptide that inactivates its precursor form

Naotaka Tsutsumi1,2, Ayumi Yokota3, Takeshi Kimura4

  • 1Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan.

Scientific Reports
|April 18, 2019
PubMed
Summary

Uncontrolled interleukin-18 (IL-18) secretion causes inflammatory diseases. Researchers discovered an interaction between IL-18 and its propeptide, suggesting a new therapeutic target for peptide-based IL-18 inhibitors.

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