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Mucinous rectal cancer: concepts and imaging challenges.
Natally Horvat1, Thomas A Hope2, Perry J Pickhardt3
1Department of Radiology, Hospital Sirio-Libanes, São Paulo, SP, Brazil.
Abdominal Radiology (New York)
|April 18, 2019
Summary
This study discusses rectal adenocarcinoma with mucinous components, an uncommon cancer. Differentiating mucin post-treatment on imaging is a key challenge for radiologists.
Area of Science:
- Gastroenterology
- Oncology
- Radiology
Background:
- Rectal adenocarcinoma with mucinous components is rare, with subtypes including mucinous adenocarcinoma and signet-ring cell carcinoma.
- Mucin can also represent a treatment response pattern after neoadjuvant therapy.
- Imaging characteristics of mucin include high T2 signal intensity, low CT attenuation, and potential negative 18-fluorodeoxyglucose uptake on PET.
Purpose of the Study:
- To highlight the challenges in differentiating cellular and acellular mucin on imaging after neoadjuvant chemoradiotherapy (CRT).
- To inform radiologists about the limitations of various imaging modalities for rectal cancer staging and restaging.
Main Methods:
- Review of imaging features of mucin in rectal adenocarcinoma across different modalities.
- Analysis of challenges in distinguishing mucin subtypes post-neoadjuvant treatment.
Main Results:
- Cellular and acellular mucin exhibit similar imaging features after neoadjuvant CRT, posing a diagnostic challenge.
- Current imaging modalities have limitations in accurately characterizing mucin components.
Conclusions:
- Radiologists must be aware of the pros, cons, and limitations of imaging techniques for rectal cancer.
- Accurate interpretation of radiological findings is crucial to avoid misdiagnosis of mucinous rectal adenocarcinoma and its treatment response.
Keywords:
Computed tomographyMagnetic resonance imagingMucinPositron emission tomographyRectal neoplasmsMore Related Videos
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