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The relationship between adrenal incidentalomas and mortality risk
Michio Taya1,2, Viktoriya Paroder3,4, Eran Bellin5,6
1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 E 210th Street, Bronx, New York, NY, 10467, USA. michio.taya@gmail.com.
European Radiology
|April 18, 2019
Summary
Patients with adrenal incidentalomas face higher all-cause mortality risk. These adrenal findings may serve as a significant biomarker for increased mortality and chronic illnesses.
Area of Science:
- Endocrinology
- Oncology
- Cardiology
- Pulmonology
Background:
- Adrenal incidentalomas are common findings on abdominal imaging.
- Their association with long-term mortality and chronic disease is not well-established.
Purpose of the Study:
- To investigate the all-cause mortality risk in patients diagnosed with adrenal incidentaloma.
- To explore the association between adrenal incidentalomas and the incidence of various chronic illnesses.
Main Methods:
- Retrospective cohort study of adult patients undergoing abdominal CT scans.
- Identification of adrenal incidentaloma cases and matching with controls without adrenal nodules.
- Mortality data ascertained through in-hospital records and the National Death Index.
- Survival analysis using Kaplan-Meier curves and Cox proportional hazards models.
Main Results:
- Adrenal incidentalomas were associated with a significantly higher risk of all-cause mortality (aHR 1.14).
- Exploratory analyses indicated increased incidence of malignancy, diabetes, heart failure, peripheral vascular disease, renal disease, and chronic pulmonary disease in the incidentaloma group.
- Adrenal incidentaloma size was not found to be predictive of mortality.
Conclusions:
- Adrenal incidentalomas are linked to increased all-cause mortality.
- These findings suggest adrenal incidentalomas may function as a clinically significant biomarker for adverse health outcomes.
- Association with chronic illnesses warrants further investigation and clinical consideration.
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