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Endogenous aspergillus endophthalmitis
Abstract:
A 27-year-old man with a history of intravenous-narcotic abuse presented with signs and symptoms suggesting fungal endophthalmitis. He underwent core vitrectomy with intravitreal injection of amphotericin B. Aspergillus flavus grew from cultures of the vitreous aspirate. There was no evidence of extraocular infection, and the patient was treated postoperatively with subconjunctival amphotericin B and oral flucytosine. Unlike previously reported cases of endogenous aspergillus endophthalmitis in drug abusers, the patient described here recovered normal visual acuity.
Insights
This case study highlights a successful treatment of fungal endophthalmitis caused by Aspergillus flavus in an intravenous-narcotic abuser, achieving normal visual acuity. The treatment involved vitrectomy, intravitreal amphotericin B, and oral flucytosine.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Endogenous fungal endophthalmitis is a severe ocular infection, often associated with intravenous drug abuse.
- Aspergillus species, particularly Aspergillus flavus, can cause devastating intraocular infections.
- Previous cases in intravenous drug abusers have often resulted in poor visual outcomes.