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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Speckle tracking echocardiography in cats with preclinical hypertrophic cardiomyopathy

Ilaria Spalla1, Adrian Boswood1, David J Connolly1

  • 1Clinical Science and Services, Royal Veterinary College, Hertfordshire, United Kingdom.

Journal of Veterinary Internal Medicine
|April 18, 2019
PubMed

Insights

Cats with preclinical hypertrophic cardiomyopathy (HCM) show reduced longitudinal and radial heart muscle function. These changes, along with left ventricular internal diameter in diastole (LVIDd), can help diagnose HCM in cats.

Area of Science:

  • Veterinary Cardiology
  • Echocardiography
  • Cardiovascular Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) in cats is associated with impaired left ventricular (LV) function.
  • Preclinical HCM in cats exhibits reduced systolic LV longitudinal and radial strain (S) and strain rate (SR), while circumferential function is preserved.

Purpose of the Study:

  • To evaluate systolic deformation in cats with preclinical HCM using speckle tracking echocardiography (STE).
  • To compare echocardiographic variables between cats with and without preclinical HCM.

Main Methods:

  • A retrospective study involving 73 client-owned cats (37 with preclinical HCM, 36 controls).
  • STE was used to calculate LV and RV longitudinal, radial, and circumferential S and SR.
  • LV mass was measured, and correlations between STE variables and LV hypertrophy were analyzed. Receiver-operating characteristic (ROC) curves were generated for HCM prediction.

Main Results:

  • Cats with HCM demonstrated significantly decreased longitudinal S and SR, and radial S and SR compared to healthy controls.
  • No significant differences in circumferential S and SR were observed between groups.
  • Cats with HCM had increased LV mass. A logistic regression model combining LV mass, MAPSE, and LVIDd yielded the highest area under the curve (0.974) for HCM identification.

Conclusions:

  • Preclinical HCM in cats is characterized by reduced longitudinal and radial myocardial deformation.
  • Decreased longitudinal deformation and LVIDd are significant indicators supporting an HCM diagnosis in feline patients.
Abstract

Keywords:
echocardiographyfelinehypertrophic cardiomyopathy

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