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Updated: Jan 26, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques
Fang Wang1, Tiewei Li1, Xiangfeng Cong1
1State Key Laboratory of Cardiovascular Disease, Center of Laboratory Medicine, Fuwai Hospital.
Background:
Noncalcified plaques (NCPs) and mixed plaques (MPs) are considered as the high-risk coronary plaques. Endothelin-1 (ET-1) is a vasoactive peptide and shows a high expression in vulnerable plaque. The aim of this study is to investigate the relationship between the bigET-1, the precursor of ET-1, and NCPs/MPs in a Chinese population.
Methods And Results:
A total of 513 patients with chest pain and suspected coronary artery disease were collected and divided into three groups with no plaques, calcified plaques, or NCPs/MPs according to the characteristics of all the plaques. It demonstrated that NCPs/MPs were associated with elevated bigET-1 (P < 0.001). Moreover, the proportion of NCPs/MPs was significantly increased from 43.3% in bigET-1 tertile 1 to 61.0% in tertile 3 group (P = 0.001). Multiple logistic regression analysis further showed that bigET-1 was an independent predictor for the presence of NCPs/MPs (odds ratio = 1.858; 95% confidence interval: 1.017-3.394; P = 0.044).
Conclusion:
The bigET-1 could be an independent predictor for the presence of NCPs/MPs.
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