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cGMP manipulation in cardiometabolic disease: chances and challenges
Jens Jordan1,2, Staffan Hildebrand3, Alexander Pfeifer3
1Institute of Aerospace Medicine, German Aerospace Center (DLR).
Current Opinion in Cardiology
|April 18, 2019
Summary
The cyclic guanosine monophosphate (cGMP) system influences both cardiovascular health and metabolism. Enhancing cGMP signaling may improve glucose metabolism, but excessive levels carry risks.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Metabolic Science
Background:
- Cardiovascular and metabolic diseases frequently coexist in patients.
- The cyclic guanosine monophosphate (cGMP) system plays a crucial role in mediating signals for nitric oxide and natriuretic peptides.
Purpose of the Study:
- To review the crosstalk between the cGMP system and the cardiovascular and metabolic systems.
- To explore the role of cGMP in oxidative metabolism and insulin signaling.
Main Methods:
- Literature review of recent studies on cGMP signaling.
- Analysis of clinical trial data regarding natriuretic peptides and cGMP.
Main Results:
- cGMP signaling, particularly via natriuretic peptides, shows promise in improving insulin sensitivity.
- Clinical trials indicate a reduced risk of type 2 diabetes mellitus progression with enhanced cGMP activity.
- Further research is required to fully elucidate these effects.
Conclusions:
- Modulating cGMP signaling offers potential benefits for glucose metabolism and cardiovascular health.
- Nonpharmacological and pharmacological interventions targeting cGMP may be beneficial.
- Caution is advised due to potential adverse cardiovascular and metabolic effects of excessive cGMP production.
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