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The sinusoids in cirrhosis. A morphometric study.

C Pesce, R Colacino

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1986
    PubMed
    Summary
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    In cirrhosis patients, sinusoidal surface area increased significantly, but sinusoidal length and volume fraction did not. These findings suggest sinusoidal changes are not a primary cause of portal hypertension in cirrhosis.

    Area of Science:

    • Hepatology
    • Pathology
    • Morphometry

    Background:

    • Cirrhosis is a major cause of liver disease.
    • Portal hypertension is a serious complication of cirrhosis.

    Purpose of the Study:

    • To investigate morphometric changes in liver sinusoids in cirrhosis.
    • To determine the relationship between sinusoidal alterations and portal hypertension.

    Main Methods:

    • Morphometric analysis of liver biopsy specimens.
    • Comparison of cirrhotic (n=12) and control (n=11) groups.
    • Evaluation of volume fraction (Vv), surface area to volume ratio (Sv), and length to volume ratio (Lv) of sinusoids.

    Main Results:

    • Sinusoidal surface area to volume ratio (Sv) was significantly higher in cirrhotic patients (P < 0.01).

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  • Sinusoidal length to volume ratio (Lv) and volume fraction (Vv) showed no significant differences between groups.
  • Sv is directly related to sinusoidal radius.

    • Conclusions:

    • Increased sinusoidal radius, indicated by higher Sv, occurs in cirrhosis.
    • Changes in sinusoidal dimensions do not appear to be a significant factor in the development of portal hypertension in cirrhosis.