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The development and characterization of Propranolol Tablets using Tapioca starch as excipient.
Julyane B M Fernandes1, Maísa T Celestino1, Maria I B Tavares2
1Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco L, Avenida Carlos Chagas Filho, 373, Cidade Universitária, Ilha do Fundão, 21945-970 Rio de Janeiro, RJ, Brazil.
Anais Da Academia Brasileira De Ciencias
|April 18, 2019
Summary
Tapioca starch shows potential for developing propranolol tablets via direct compression. Characterization confirmed physical interactions and acceptable tablet properties, with drug release following Hixson-Crowell kinetics.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Tapioca starch (TS), derived from Cassava roots, offers unique properties with high amylose content.
- Propranolol (POP) is an essential beta-blocker listed by the WHO, requiring effective oral dosage forms.
Purpose of the Study:
- To evaluate tapioca starch as an excipient for direct compression of propranolol tablets.
- To assess the physicochemical properties and drug release characteristics of the developed tablets.
Main Methods:
- Characterization using X-ray diffraction (XRD), FTIR, NMR relaxometry, and SEM.
- Evaluation of tablet properties: weight uniformity, drug content, hardness, friability, disintegration, and dissolution.
- Analysis of drug release kinetics.
Main Results:
- Spherical tapioca starch granules (mean diameter 10.09 ± 1.85 µm) were obtained.
- XRD, FTIR, and NMR indicated physical interactions between tapioca starch and propranolol.
- Tablets exhibited suitable physical characteristics (hardness 10.98 ± 0.31 N, friability 25.74 ± 0.08%), with propranolol release initiated at 45 minutes.
Conclusions:
- Tapioca starch is a viable excipient for direct compression of propranolol tablets.
- The drug release profile followed Hixson-Crowell kinetics, suggesting potential for controlled release applications.
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