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Comparative Overall Comorbidity Burden Among Patients With Hidradenitis Suppurativa

Sarah Reddy1, Andrew Strunk1, Amit Garg1

  • 1Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

JAMA Dermatology
|April 18, 2019
PubMed

Insights

Patients with hidradenitis suppurativa (HS) have a significantly higher comorbidity burden, as measured by the Charlson Comorbidity Index (CCI), compared to psoriasis patients and controls. Higher CCI scores in HS patients are linked to increased mortality risk.

Area of Science:

  • Dermatology
  • Epidemiology
  • Public Health

Background:

  • The comorbidity burden in hidradenitis suppurativa (HS) patients remains under-evaluated.
  • Understanding comorbidities is crucial for comprehensive HS patient management.

Purpose of the Study:

  • To assess and compare the standardized comorbidity burden in HS patients against psoriasis patients and a control group.
  • To investigate the association between comorbidity burden and mortality in HS.

Main Methods:

  • Cross-sectional analysis of electronic health records from October 2013 to October 2018.
  • Inclusion of 5,306 HS patients, 14,037 psoriasis patients, and 1,733,810 controls.
  • Primary outcome: mean Charlson Comorbidity Index (CCI) score; secondary outcome: 5-year mortality risk.

Main Results:

  • Matched HS patients exhibited a higher mean CCI score (1.95) than psoriasis (1.47) and control (0.95) groups.
  • 13.5% of HS patients had a CCI score of 5 or greater, associated with a nearly 5-fold increased risk of 5-year mortality.
  • Chronic pulmonary disease and diabetes were the most frequent comorbidities in HS patients.

Conclusions:

  • HS patients face a substantial comorbidity burden, exceeding that of psoriasis patients and controls.
  • Elevated comorbidity burden in HS is linked to increased mortality, underscoring the need for routine screening.
  • Multidisciplinary approaches and routine screening measures are recommended for HS management.
Abstract

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