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Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease
Kohki Okada1,2, Makoto Okabe3, Yuto Kimura4
1Department of Medical Technology and Sciences, Faculty of Health Sciences, Kyoto Tachibana University, Kyoto, Japan.
Background:
The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood.
Objective:
To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD.
Methods:
Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD.
Results:
The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins.
Conclusion:
Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD.
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