Endoscopic Resections in Inflammatory Bowel Disease: A Multicentre European Outcomes Study.

Area of Science:

• Gastroenterology
• Oncology
• Endoscopic Surgery

Background:

• Inflammatory bowel disease (IBD) significantly increases colorectal cancer risk.
• Neoplasia management in IBD patients remains a clinical challenge.
• Current guidelines favor endoscopic resection for visible lesions with clear margins.

Purpose of the Study:

• To evaluate the outcomes of neoplastic endoscopic resections in patients with inflammatory bowel disease.
• To compare the efficacy of different endoscopic resection techniques based on lesion characteristics.

Main Methods:

• Multicenter retrospective cohort study.
• Involved 93 patients with 119 visible dysplasia lesions.
• Analyzed outcomes of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR).

Main Results:

• Endoscopic submucosal dissection (ESD) was preferred for larger (>20 mm) and fibrotic lesions.
• Endoscopic mucosal resection (EMR) was predominantly used for smaller (<20 mm) and non-fibrotic lesions.
• En-bloc resection rates were comparable between EMR (63%) and ESD/KAR (65.9%); recurrence and complication rates were low.

Conclusions:

• Endoscopic submucosal dissection (ESD) is optimal for larger, fibrotic lesions in IBD.
• Endoscopic mucosal resection (EMR) is suitable for smaller, non-fibrotic lesions.
• Both EMR and ESD are feasible and effective for neoplastic endoscopic resections in colitis.