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Updated: Jan 26, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

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The Status and Impact of Clinical Tumor Genome Sequencing

Kenna R Mills Shaw1, Anirban Maitra1

  • 1Khalifa Bin Zayed Institute for Personalized Cancer Therapy and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;

Annual Review of Genomics and Human Genetics
|April 18, 2019
PubMed

Insights

Advances in tumor genome sequencing, including whole-exome and whole-genome sequencing, have overcome technical hurdles. The focus now shifts to optimizing the use of this data for precision medicine across diverse cancer types.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • DNA alterations are known drivers of tumorigenesis.
  • Targeted therapeutics aim to counteract these specific genetic changes.
  • Early tumor DNA sequencing focused on actionable hotspots with approved therapies.

Purpose of the Study:

  • To review the evolution of tumor genome sequencing technologies.
  • To highlight the innovations enabling clinical application of sequencing.
  • To identify future opportunities in precision oncology.

Main Methods:

  • Review of technological advancements in DNA sequencing.
  • Discussion of improvements in clinical laboratory workflows.
  • Analysis of the transition from research to clinical settings.

Main Results:

  • Technological improvements enabled large-scale whole-exome and whole-genome sequencing.
  • Clinical laboratory innovations improved turnaround time and reliability for archived samples.
  • Tumor genome sequencing now faces minimal technical or financial barriers.

Conclusions:

  • Tumor genome sequencing is now widely accessible.
  • The primary challenge is now the optimal utilization of sequencing data.
  • Future efforts should focus on leveraging genomic data for broader precision medicine applications.
Keywords:
molecular diagnosticsnext-generation sequencingprecision medicine

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