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The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase
Yoko Nitta1, Hideyuki Ito1, Hirohumi Komori2
1a Department of Nutritional Science, Faculty of Health and Welfare Science , Okayama Prefectural University , Soja-shi, Okayama , Japan.
Abstract:
Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation. Abbreviations: HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate.
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