Related Experiment Video
Updated: Jan 26, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
Alexander P Y Brown1, Lee Cossell1, Troy W Margrie1
1The Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, UK.
Abstract:
This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function.
Related Concept Videos
What is a Sensory System?
Sensory Functions of the Skin
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Intrinsically Disordered Proteins
Visual System
Once through the pupil, the light passes through the lens, a...
GTPases and their Regulation
Large G-proteins,...
Testosterone: Functions and Regulation

