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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Oligometastatic Prostate Cancer.

J Navrátil, A Poprach, R Lakomý

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |April 19, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Oligometastatic prostate cancer, defined by limited metastases, benefits from targeted therapies like surgery or radiotherapy. Selected patients may achieve improved survival by delaying systemic treatment with these aggressive approaches.

    Keywords:
    PET/CTandrogen-deprivation therapyoligometastatic diseaseprostate cancerprostatectomyradiotherapy

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    Area of Science:

    • Oncology
    • Urology
    • Radiation Oncology

    Background:

    • Oligometastatic prostate cancer is increasingly diagnosed due to improved imaging.
    • Treatment intensification targeting primary and metastatic lesions shows promise in delaying systemic therapy and improving survival.
    • Uncertainties remain regarding the definition of oligometastatic disease and patient selection for aggressive treatment.

    Purpose of the Study:

    • To provide an updated review of oligometastatic prostate cancer.
    • To present current literature on diagnostic imaging and treatment options, including surgery and radiotherapy.
    • To clarify the definition and management of oligometastatic prostate cancer.

    Main Methods:

    • Literature review of contemporary studies on oligometastatic prostate cancer.
    • Analysis of diagnostic imaging advancements.
    • Evaluation of surgical and radiotherapeutic treatment modalities.

    Main Results:

    • Limited data from small retrospective studies suggest survival benefits from targeted therapy for oligometastatic prostate cancer.
    • Stereotactic radiotherapy is frequently used with minimal side effects.
    • Previous definitions accepted 3-5 metastatic lesions, but patient subgroups were heterogeneous.

    Conclusions:

    • Selected patients with oligometastatic prostate cancer benefit from targeted, personalized treatment.
    • Further research is needed to refine the definition and treatment strategies for oligometastatic prostate cancer.
    • Metastasis-targeted therapy can be a valuable option for specific patient subgroups.