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High Level of Circulating Microparticles in Patients with BCR/ABL Negative Myeloproliferative Neoplasm - a Pilot

M H Aswad, J Kissová, L Rihova

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |April 19, 2019
    PubMed
    Abstract

    Insights

    Microparticles (MPs) are elevated in myeloproliferative neoplasms (MPNs), contributing to thrombosis risk. Platelet and erythrocyte MPs, along with their procoagulation activity, are significantly higher in MPN patients compared to healthy individuals.

    Area of Science:

    • Hematology
    • Oncology
    • Vascular Biology

    Background:

    • Microparticles (MPs) are cell-derived vesicles linked to thromboembolic diseases and malignancies.
    • BCR/ABL negative myeloproliferative neoplasms (MPNs) carry a high risk of thrombosis.
    • MPs are implicated in initiating and amplifying thrombogenesis.

    Purpose of the Study:

    • To assess the clinical significance of circulating MPs in BCR/ABL-negative MPN patients.
    • To compare MP levels and procoagulation activity between MPN patients and healthy controls.
    • To investigate MP differences among MPN subtypes and their association with JAK2V617F mutation.

    Main Methods:

    • Flow cytometry was used to analyze MPs in 179 MPN patients across 417 samples.
    • MP procoagulation activity was measured using the Zymuphen MP-activity assay in 274 samples.
    • Comparison groups included healthy individuals and different MPN subtypes (polycythemia vera, essential thrombocythemia, primary myelofibrosis).

    Main Results:

    • MPN patients exhibited significantly higher absolute and relative counts of platelet MPs and erythrocyte MPs compared to healthy controls.
    • The procoagulation activity of MPs was significantly elevated in MPN patients.
    • Primary myelofibrosis patients showed lower platelet MP counts than polycythemia vera and essential thrombocythemia patients. JAK2V617F mutation correlated with increased platelet MPs.

    Conclusions:

    • Circulating MPs, particularly platelet and erythrocyte MPs, are significantly elevated in MPN patients, suggesting a role in hypercoagulation.
    • Further research is necessary to elucidate the precise clinical implications of MPs in thrombotic events within the MPN context.
    • Understanding MP levels and activity may offer insights into thrombosis risk stratification in MPN.
    Keywords:
    Janus Kinase 2microparticlesmyeloproliferative disordersprocoagulation activitythrombosis

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